Article
Structural basis of androgen receptor binding to selective androgen response elements.
Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2004
Shaffer Paul L, Jivan Arif, Dollins D Eric, Claessens Frank, Gewirth Daniel T
Abstract excerpt
Steroid receptors bind as dimers to a degenerate set of response elements containing inverted repeats of a hexameric half-site separated by 3 bp of spacer (IR3). Naturally occurring selective androgen response elements have recently been identified that resemble direct repeats of the hexameric half-site (ADR3). The 3D crystal structure of the androgen receptor (AR) DNA-binding domain bound to a selective ADR3...
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