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Article

Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 1997

Masuyama H, Brownfield C M, St-Arnaud R, MacDonald P N

Abstract excerpt

A ligand-dependent transcriptional activation domain (AF-2) exists in region E of the nuclear receptors. This highly conserved domain may contact several coactivators that are putatively involved in nuclear receptor-mediated transcription. In this study, a panel of vitamin D receptor (VDR) AF-2 m...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Animals
COS Cells
Ligands
Molecular Sequence Data
Mutation
Nuclear Proteins
Nuclear Receptor Interacting Protein 1
Protein Folding
Receptors, Calcitriol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Transcriptional Activation

Vitamin D

Source

Identifiers

PMID: 9280066
DOI: 10.1210/mend.11.10.9990

Genes

VDR
SRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9280066-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction.PMID 9280066Read ↗

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