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Article

Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 1997

Masuyama H, Brownfield C M, St-Arnaud R, MacDonald P N

Abstract excerpt

A ligand-dependent transcriptional activation domain (AF-2) exists in region E of the nuclear receptors. This highly conserved domain may contact several coactivators that are putatively involved in nuclear receptor-mediated transcription. In this study, a panel of vitamin D receptor (VDR) AF-2 mutants was created to examine the importance of several conserved residues in VDR-activated transcription. Two AF-2...

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Source

Identifiers

PMID: 9280066
DOI: 10.1210/mend.11.10.9990

Genes

VDR
SRC

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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