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Article

Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid.

Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 1996

Zhang Y, Dhandayuthapani S, Deretic V

Abstract excerpt

The exceptional sensitivity of Mycobacterium tuberculosis to isonicotinic acid hydrazide (INH) lacks satisfactory definition. M. tuberculosis is a natural mutant in oxyR, a central regulator of peroxide stress response. The ahpC gene, which encodes a critical subunit of alkyl hydroperoxide reductase, is one of the targets usually controlled by oxyR in bacteria. Unlike in mycobacterial species less susceptible to...

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Identifiers

PMID: 8917570
DOI: 10.1073/pnas.93.23.13212
PMCID: PMC24072

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Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid.PMID 8917570Read ↗

The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid.Semantic proximity Read ↗

Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid.Semantic proximity Read ↗

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex.Semantic proximity Read ↗

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC.Semantic proximity Read ↗

The mechanism of isoniazid killing: clarity through the scope of genetics.Semantic proximity Read ↗

Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.Semantic proximity Read ↗

Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium.Semantic proximity Read ↗

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.Semantic proximity Read ↗

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.Semantic proximity Read ↗

Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the DrugSemantic proximity Read ↗

Prevalence and resistance spectrum of ahpC mutations in isoniazid-resistant Mycobacterium tuberculosis isolates.Semantic proximity Read ↗

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