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Article

Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid.

Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 1996

Zhang Y, Dhandayuthapani S, Deretic V

Abstract excerpt

The exceptional sensitivity of Mycobacterium tuberculosis to isonicotinic acid hydrazide (INH) lacks satisfactory definition. M. tuberculosis is a natural mutant in oxyR, a central regulator of peroxide stress response. The ahpC gene, which encodes a critical subunit of alkyl hydroperoxide reduct...

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Identifiers

PMID: 8917570
DOI: 10.1073/pnas.93.23.13212
PMCID: PMC24072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8917570-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid.PMID 8917570Read ↗

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Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium.Semantic proximity Read ↗

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