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Article

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC.

PloS one - 1 Jan 2016

Nieto R Luisa Maria, Mehaffy Carolina, Creissen Elizabeth, Troudt JoLynn, Troy Amber, Bielefeldt-Ohmann Helle, Burgos Marcos, Izzo Angelo, Dobos Karen M

Abstract excerpt

In the last decade, there were 10 million new tuberculosis cases per year globally. Around 9.5% of these cases were caused by isoniazid resistant (INHr) Mycobacterium tuberculosis (Mtb) strains. Although isoniazid resistance in Mtb is multigenic, mutations in the catalase-peroxidase (katG) gene predominate among the INHr strains. The effect of these drug-resistance-conferring mutations on Mtb fitness and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27893795
DOI: 10.1371/journal.pone.0166807
PMCID: PMC5125630

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Source receipt: pubmed, retrieved 7 Sept 2026.

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