Article
Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid.
Molecular microbiology - 1 Sept 1995
Deretic V, Philipp W, Dhandayuthapani S, Mudd M H, Curcic R, Garbe T, Heym B, Via L E, Cole S T
Abstract excerpt
The systems participating in detoxification of reactive oxygen intermediates in Mycobacterium tuberculosis are believed to play a dual role in the biology of this highly adapted human pathogen: (i) they may contribute to the survival of this bacterium in the host; and (ii) alterations in the gene encoding catalase/peroxidase have been linked to this organism's resistance to the front-line antituberculosis drug...
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