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Article

Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium.

Molecular microbiology - 1 Mar 1998

Mdluli K, Swanson J, Fischer E, Lee R E, Barry C E

Abstract excerpt

Isoniazid (INH), which acts by inhibiting mycolic acid biosynthesis, is very potent against the tuberculous mycobacteria. It is about 100-fold less effective against Mycobacterium avium. This difference has often been attributed to a decreased permeability of the cell wall. We measured the rate of conversion of radiolabelled INH to 4-pyridylmethanol by whole cells and cell-free extracts and estimated the...

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Identifiers

PMID: 9570407
DOI: 10.1046/j.1365-2958.1998.00774.x

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