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Article

The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid.

Nature biotechnology - 1 Nov 1996

Deretic V, Pagán-Ramos E, Zhang Y, Dhandayuthapani S, Via L E

Abstract excerpt

Mycobacterium tuberculosis is a natural mutant in oxyR, a close homolog of the central regulator of peroxide stress response in enteric bacteria. Inactivation of oxyR is specific for M. tuberculosis and other members of the M. tuberculosis complex. This phenomenon appears as a paradox due to the...

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PMID: 9634820
DOI: 10.1038/nbt1196-1557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9634820-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid.PMID 9634820Read ↗

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Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the DrugSemantic proximity Read ↗

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