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Article

Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.

Science (New York, N.Y.) - 14 Jun 1996

Sherman D R, Mdluli K, Hickey M J, Arain T M, Morris S L, Barry C E, Stover C K

Abstract excerpt

Mutations that eliminate KatG catalase-peroxidase activity prevent activation of isoniazid and are a major mechanism of resistance to this principal drug for the treatment of Mycobacterium tuberculosis infections. However, the loss of KatG activity in clinical isolates seemed paradoxical because...

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Identifiers

PMID: 8658136
DOI: 10.1126/science.272.5268.1641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8658136-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.PMID 8658136Read ↗

Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.Semantic proximity Read ↗

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC.Semantic proximity Read ↗

Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid.Semantic proximity Read ↗

Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid.Semantic proximity Read ↗

Isoniazid activation defects in recombinant Mycobacterium tuberculosis catalase-peroxidase (KatG) mutants evident in InhA inhibitor production.Semantic proximity Read ↗

Compensatory increase in ahpC gene expression and its role in protecting Burkholderia pseudomallei against reactive nitrogen intermediates.Semantic proximity Read ↗

Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosisSemantic proximity Read ↗

The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.Semantic proximity Read ↗

Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.Semantic proximity Read ↗

ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex.Semantic proximity Read ↗

Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Roles of the three Mycobacterium smegmatis katG genes for peroxide detoxification and isoniazid susceptibility.Semantic proximity Read ↗

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