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Article

The mechanism of isoniazid killing: clarity through the scope of genetics.

Annual review of microbiology - 1 Jan 2007

Vilchèze Catherine, Jacobs William R

Abstract excerpt

Isoniazid (INH) is one of the most efficient drugs for the treatment of Mycobacterium tuberculosis infections. Despite its rather simple chemical structure, the mechanism by which INH kills M. tuberculosis is complex. A full understanding of the mechanisms of action of INH required the development of genetic tools in M. tuberculosis. Herein, we discuss the different hypotheses that have been used to describe INH...

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Identifiers

PMID: 18035606
DOI: 10.1146/annurev.micro.61.111606.122346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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