A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast Schizosaccharomyces pombe.

doi:10.1007/BF02172398

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast Schizosaccharomyces pombe.

Molecular & general genetics : MGG - 16 Oct 1996

Casso D, Beach D

Abstract excerpt

A strong growth inhibition is observed when the human p53 tumor suppressor gene product is expressed in the fission yeast Schizosaccharomyces pombe. This growth inhibition is specific for wild-type p53; mutant alleles of p53 derived from human tumors show a greatly decreased ability to inhibit gr...

Topics

Cell Division
Cloning, Molecular
Gene Expression Regulation, Fungal
Genes, Suppressor
Genes, p53
Humans
Hydrogen Peroxide
Molecular Sequence Data
Mutation
Oxygen
Recombinant Proteins
Schizosaccharomyces
Sequence Homology, Amino Acid
Thioredoxin-Disulfide Reductase
Transcription Factors
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8914513
DOI: 10.1007/BF02172398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8914513-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics