Article
Putative dehydrogenase tms1 suppresses growth arrest induced by a p53 tumour mutant in fission yeast.
European journal of biochemistry - 15 Oct 1993
Wagner P, Grimaldi M, Jenkins J R
Abstract excerpt
Expression of a human tumour-derived p53 His 273 cDNA induced growth arrest in fission yeast Schizosaccharomyces pombe. Based on the p53-induced growth arrest, we cloned an extragenic suppressor, termed tms1, by complementation. The open reading frame of the tms1 gene corresponded to a protein of 347 amino acids with a calculated mass of 37380 Da. The transcriptional start site of the tms1 gene was mapped and, in...
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