Article
Putative dehydrogenase tms1 suppresses growth arrest induced by a p53 tumour mutant in fission yeast.
European journal of biochemistry - 15 Oct 1993
Wagner P, Grimaldi M, Jenkins J R
Abstract excerpt
Expression of a human tumour-derived p53 His 273 cDNA induced growth arrest in fission yeast Schizosaccharomyces pombe. Based on the p53-induced growth arrest, we cloned an extragenic suppressor, termed tms1, by complementation. The open reading frame of the tms1 gene corresponded to a protein of...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA, Complementary
- Fungal Proteins
- Gene Expression
- Genes, Fungal
- Genes, Suppressor
- Genes, p53
- Genetic Complementation Test
- Humans
- Immunoblotting
- L-Iditol 2-Dehydrogenase
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Oxidoreductases
- Restriction Mapping