Article
Human p53 inhibits growth in Schizosaccharomyces pombe.
Molecular and cellular biology - 1 Apr 1992
Bischoff J R, Casso D, Beach D
Abstract excerpt
Overexpression of wild-type p53 in mammalian cells blocks growth. We show here that the overexpression of wild-type human p53 in the fission yeast Schizosaccharomyces pombe also blocks growth, whereas the overexpression of mutant forms of p53 does not. The p53 polypeptide is located in the nucleus and is phosphorylated at both the cdc2 site and the casein kinase II site in S. pombe. A new dominant mutation of...
Topics
- Alleles
- Base Sequence
- Cell Division
- Gene Expression Regulation
- Genes, Dominant
- Genome, Human
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Schizosaccharomyces
- Tumor Suppressor Protein p53