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Article

Structure of the Malaria Antigen AMA1 in Complex with a Growth-Inhibitory Antibody

26 Sept 2007

Abstract excerpt

Identifying functionally critical regions of the malaria antigen AMA1 (apical membrane antigen 1) is necessary to understand the significance of the polymorphisms within this antigen for vaccine development. The crystal structure of AMA1 in complex with the Fab fragment of inhibitory monoclonal antibody 1F9 reveals that 1F9 binds to the AMA1 solvent-exposed hydrophobic trough, confirming its importance. 1F9 uses...

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PMID: 17907804
DOI: 10.1371/journal.ppat.0030138

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