Article
Allele frequency-based analyses robustly map sequence sites under balancing selection in a malaria vaccine candidate antigen.
Genetics - 1 Oct 2003
Polley Spencer D, Chokejindachai Watcharee, Conway David J
Abstract excerpt
The Plasmodium falciparum apical membrane antigen 1 (AMA1) is a leading candidate for a malaria vaccine. Here, within-population analyses of alleles from 50 Thai P. falciparum isolates yield significant evidence for balancing selection on polymorphisms within the disulfide-bonded domains I and III of the surface accessible ectodomain of AMA1, a result very similar to that seen previously in a Nigerian population....
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