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<i>Anopheles gambiae</i> TEP1 forms a complex with the coiled-coil domain of LRIM1/APL1C following a conformational change in the thioester domain

2019-02-14

Abstract excerpt

The complement-like protein thioester-containing protein 1 (TEP1) is a key factor in the immune response of the malaria vector Anopheles gambiae to pathogens. Multiple allelic variants of TEP1 have been identified in laboratory strains and in the field, and are correlated with distinct immunophenotypes. TEP1 is tightly regulated by conformational changes induced by cleavage in a protease-sensitive region. Cleaved...

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Literature Corpus work
1b5b591c-b8ad-5182-849a-e7bb7a63b22a
DOI
10.1101/550475
Open publication

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