Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hsp90 Regulates Androgen Receptor Hormone Binding Affinity in Vivo

1 Nov 1996

Abstract excerpt

The regulation of human androgen receptor (AR) by the molecular chaperone Hsp90 was investigated using the yeast Saccharomyces cerevisiae as a model system. These studies were performed in strains expressing a conditional temperature-sensitive mutant allele of the hsp82 gene, which encodes Hsp90 protein. At the restrictive temperature in the mutant, there is a decrease in hormone-dependent transactivation by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exercise and Physiological Responses
Share to Heat shock proteins research
Share to Hormonal and reproductive studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8910505
DOI: 10.1074/jbc.271.45.28697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hsp90 Regulates Androgen Receptor Hormone Binding Affinity in VivoPMID 8910505Read ↗

Uncoupling of hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptor.Semantic proximity Read ↗

A role for Hsp90 in retinoid receptor signal transduction.Semantic proximity Read ↗

Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase.Semantic proximity Read ↗

Hsp90 mutants disrupt glucocorticoid receptor ligand binding and destabilize aporeceptor complexes.Semantic proximity Read ↗

Functional and physical interaction between yeast Hsp90 and Hsp70.Semantic proximity Read ↗

Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function.Semantic proximity Read ↗

Control of estrogen receptor ligand binding by Hsp90.Semantic proximity Read ↗

The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo.Semantic proximity Read ↗

Hsp90 as a therapeutic target in prostate cancer.Semantic proximity Read ↗

The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1.Semantic proximity Read ↗

Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast.Semantic proximity Read ↗

Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.