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Article

The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1.

The Journal of biological chemistry - 1 Mar 2002

Lee Hee Chul, Hon Thomas, Zhang Li

Abstract excerpt

Hsp90 plays critical roles in the proper functioning of a wide array of eukaryotic signal transducers such as steroid receptors and tyrosine kinases. Hap1 is a naturally occurring substrate of Hsp90 in Saccharomyces cerevisiae. Hap1 transcriptional activity is precisely and stringently controlled by heme. Previous biochemical studies suggest that in the absence of heme, Hap1 is bound to Hsp90 and other proteins,...

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PMID: 11751848
DOI: 10.1074/jbc.M106951200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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