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Article

Control of estrogen receptor ligand binding by Hsp90.

The Journal of steroid biochemistry and molecular biology - 1 Apr 2000

Fliss A E, Benzeno S, Rao J, Caplan A J

Abstract excerpt

The molecular chaperone Hsp90 interacts with unliganded steroid hormone receptors and regulates their activity. We have analyzed the function of yeast and mammalian Hsp90 in regulating the ability of the human estrogen receptor (ER) to bind ligands in vivo and in vitro. Using the yeast system, we show that the ER expressed in several different hsp82 mutant strains binds reduced amounts of the synthetic estrogen...

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PMID: 10822011
DOI: 10.1016/s0960-0760(00)00037-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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