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Article

Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function.

Cell reports - 19 Apr 2016

Mishra Parul, Flynn Julia M, Starr Tyler N, Bolon Daniel N A

Abstract excerpt

To probe the mechanism of the Hsp90 chaperone that is required for the maturation of many signaling proteins in eukaryotes, we analyzed the effects of all individual amino acid changes in the ATPase domain on yeast growth rate. The sensitivity of a position to mutation was strongly influenced by proximity to the phosphates of ATP, indicating that ATPase-driven conformational changes impose stringent physical...

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Identifiers

PMID: 27068472
DOI: 10.1016/j.celrep.2016.03.046
PMCID: PMC4838542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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