Hsp90 mutants disrupt glucocorticoid receptor ligand binding and destabilize aporeceptor complexes.

doi:10.1074/jbc.270.49.29433

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Article

Hsp90 mutants disrupt glucocorticoid receptor ligand binding and destabilize aporeceptor complexes.

The Journal of biological chemistry - 8 Dec 1995

Bohen S P

Abstract excerpt

In order to attain competence to respond to hormone, certain steroid hormone receptors must be assembled into hetero-oligomeric aporeceptor complexes, containing Hsp90 and other proteins. Members of the Hsp90 gene family are highly conserved, strongly expressed, and required for viability in euka...

Topics

HSP90 Heat-Shock Proteins
Heat-Shock Proteins
Ligands
Mutation
Receptors, Glucocorticoid
Saccharomyces cerevisiae Proteins
Signal Transduction

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