Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor.

Abstract excerpt

1. Whole-cell patch-clamp recordings were used to study voltage-dependent facilitation of Ca2+ currents and excessive Ca2+ tail current in skeletal myoballs cultured from wild-type and transgenic mice expressing a null mutation of the ryanodine receptor (RyR) type 1 (dyspedic myoballs). 2. Ca2+ c...

Topics

• Animals
• Animals, Newborn
• Calcium Channels
• Calmodulin-Binding Proteins
• Electrophysiology
• Membrane Potentials
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Muscle Proteins
• Muscle, Skeletal
• Mutation
• Patch-Clamp Techniques
• Ryanodine Receptor Calcium Release Channel