Article
Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.
The Journal of physiology - 1 Jun 1997
Ikemoto T, Komazaki S, Takeshima H, Nishi M, Noda T, Iino M, Endo M
Abstract excerpt
1. We generated mice with targeted disruptions in the genes for both ryanodine receptor type 1 (RyR-1) and type 3 (RyR-3) to study the functional roles of RyR subtypes in skeletal muscle. 2. In permeabilized myocytes lacking both the RyRs, the Ca(2+)-induced Ca2+ release (CICR) mechanism was comp...
Topics
- Animals
- Calcium
- Calcium Channels
- Calmodulin-Binding Proteins
- Chlorides
- In Vitro Techniques
- Mice
- Mice, Neurologic Mutants
- Microscopy, Electron
- Microtubules
- Muscle Fibers, Skeletal
- Muscle Proteins
- Muscle, Skeletal
- Mutation
- Ryanodine Receptor Calcium Release Channel