Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preclinical pharmacological in vitro investigations on low chloride conductance myotonia: effects of potassium regulation.

Pflugers Archiv : European journal of physiology - 1 Oct 2020

Hoppe Kerstin, Chaiklieng Sunisa, Lehmann-Horn Frank, Jurkat-Rott Karin, Wearing Scott, Klingler Werner

Abstract excerpt

In myotonia, reduced Cl- conductance of the mutated ClC-1 channels causes hindered muscle relaxation after forceful voluntary contraction due to muscle membrane hyperexcitability. Repetitive contraction temporarily decreases myotonia, a phenomena called "warm up." The underlying mechanism for the reduction of hyperexcitability in warm-up is currently unknown. Since potassium displacement is known to reduce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chloride Channels
Share to Chlorides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to KCNQ Potassium Channels

Share to Large-Conductance Calcium-Activated Potassium Channels

Share to Muscle Contraction

Share to Myotonia Congenita

Share to Potassium

Share to Potassium Channel Blockers

Source

Identifiers

PMID: 32748018
DOI: 10.1007/s00424-020-02410-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preclinical pharmacological in vitro investigations on low chloride conductance myotonia: effects of potassium regulation.PMID 32748018Read ↗

Mouse models of non-dystrophic and dystrophic myotonia exhibit nociplastic pain-like behaviorsSemantic proximity Read ↗

Myotonia congenita.Semantic proximity Read ↗

Efficacy of Retigabine in Treating Weakness in a Mouse Model of Hypokalemic Periodic Paralysis.Semantic proximity Read ↗

Efficacy of a K+ Channel Agonist, XEN1101, For Preserving Contractility in Mouse Models of Hypokalemic Periodic Paralysis.Semantic proximity Read ↗

Extracellular magnesium and calcium reduce myotonia in ClC-1 inhibited rat muscle.Semantic proximity Read ↗

Potassium dependent rescue of a myopathy with core-like structures in mouse.Semantic proximity Read ↗

Clinical evaluation and cellular electrophysiology of a recessive CLCN1 patient.Semantic proximity Read ↗

The myotonia congenita mutation A331T confers a novel hyperpolarization-activated gate to the muscle chloride channel ClC-1.Semantic proximity Read ↗

A novel alteration of muscle chloride channel gating in myotonia levior.Semantic proximity Read ↗

Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis.Semantic proximity Read ↗

ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation.Semantic proximity Read ↗

Cold extends electromyography distinction between ion channel mutations causing myotonia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.