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Article

Attenuated Ca(2+) release in a mouse model of limb girdle muscular dystrophy 2A.

Skeletal muscle - 1 Jan 2016

DiFranco Marino, Kramerova Irina, Vergara Julio L, Spencer Melissa Jan

Abstract excerpt

BACKGROUND: Mutations in CAPN3 cause limb girdle muscular dystrophy type 2A (LGMD2A), a progressive muscle wasting disease. CAPN3 is a non-lysosomal, Ca-dependent, muscle-specific proteinase. Ablation of CAPN3 (calpain-3 knockout (C3KO) mice) leads to reduced ryanodine receptor (RyR1) expression and abnormal Ca2+/calmodulin-dependent protein kinase II (Ca-CaMKII)-mediated signaling. We previously reported that...

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Topics

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Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
Share to Calcium Channels, L-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Signaling

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Share to Muscle Fibers, Skeletal

Share to Muscular Dystrophies, Limb-Girdle

Share to Ryanodine Receptor Calcium Release Channel

Source

Open in PubMed Open full text

Identifiers

PMID: 26913171
DOI: 10.1186/s13395-016-0081-y
PMCID: PMC4765215

Genes

CAPN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Attenuated Ca(2+) release in a mouse model of limb girdle muscular dystrophy 2A.PMID 26913171Read ↗

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