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Article

Preferential transmission of the high activity allele of COMT in schizophrenia.

Psychiatric genetics - 1 Jan 1996

Li T, Sham P C, Vallada H, Xie T, Tang X, Murray R M, Liu X, Collier D A

Abstract excerpt

Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline. It exists in common high and low activity forms. The low activity form is the result of an amino acid substitution (val-108-met) which reduces the thermostability of the enzyme [Lotta et al. (1994) Biochemistry, 34, 4202-4210]. We have genotyped this polymorphism in 178 trios consisting of...

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Source

Identifiers

PMID: 8902889
DOI: 10.1097/00041444-199623000-00005

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Preferential transmission of the high activity allele of COMT in schizophrenia.PMID 8902889Read ↗

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Is COMT a susceptibility gene for schizophrenia?Semantic proximity Read ↗

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Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study.Semantic proximity Read ↗

Catechol-O-methyltransferase low activity genotype (COMTLL) is associated with low levels of COMT protein in human hepatocytes.Semantic proximity Read ↗

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