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Article

Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2003

Strous Rael D, Nolan Karen A, Lapidus Raya, Diaz Libna, Saito Takuya, Lachman Herbert M

Abstract excerpt

We have previously reported that increased aggressive behavior in schizophrenic patients may be associated with a polymorphism at codon 158 of the catechol O-methyltransferase (COMT) gene that encodes a low enzyme activity variant. The finding has been replicated by one group, but not others. The discordant findings could be due to statistical errors or methodological issues in the assessment of...

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Source

Identifiers

PMID: 12815735
DOI: 10.1002/ajmg.b.20021

Genes

COMT
MAOA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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