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Article

Genetic control of interleukin 12 responsiveness: implications for disease pathogenesis.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 1997

Gorham J D, Güler M L, Murphy K M

Abstract excerpt

We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysis of the differential control of IL-12 responsiveness led to the identification of a controlling locus on the middle...

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PMID: 9253713
DOI: 10.1007/s001090050135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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