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Article

SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Feb 2007

Pal Bhupinder, Chan Nickie C, Helfenbaum Leon, Tan Kaeling, Tansey William P, Gething Mary-Jane

Abstract excerpt

The Saccharomyces cerevisiae basic leucine zipper transcription factor Hac1p is synthesized in response to the accumulation of unfolded polypeptides in the lumen of the endoplasmic reticulum (ER), and it is responsible for up-regulation of approximately 5% of all yeast genes, including ER-resident chaperones and protein-folding catalysts. Hac1p is one of the most short-lived yeast proteins, having a half-life of...

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PMID: 17108329
DOI: 10.1091/mbc.e06-04-0304
PMCID: PMC1783797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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