Article
Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes.
Blood - 15 Mar 1995
Zhu D, Oscier D G, Stevenson F K
Abstract excerpt
Splenic lymphoma with villous lymphocytes (SLVL) is a recently defined subgroup of chronic B-cell lymphoproliferative diseases. The characteristic morphology of the tumor cells, together with phenotypic and cytogenetic findings, indicate that it is a distinct entity, but the nature of the cell or origin and its relationship to other low-grade lymphomas is unclear. For B-cell tumors, analysis of the variable...
Topics
- Aged
- Aged, 80 and over
- Amino Acid Sequence
- Animals
- Base Sequence
- Female
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Lymphoma, B-Cell