A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.

Article

A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.

Cancer research - 1 Nov 1996

Cascorbi I, Brockmöller J, Roots I

Abstract excerpt

This study reports a C-->A transversion at position 4887 in exon 7 of cytochrome P4501A1 (CYP1A1), resulting in a threonine-asparagine exchange in codon 461. The polymorphism is located directly beside the known codon 462-Ile/Val mutation (m2) near the heme binding region. The C4887A mutation lea...

Topics

Aged
Cytochrome P-450 CYP1A1
Exons
Female
Genetic Linkage
Genotype
Humans
Lung Neoplasms
Male
Middle Aged
Mutation
Polymorphism, Genetic

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