Article
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.
Carcinogenesis - 1 May 2003
Hung Rayjean J, Boffetta Paolo, Brockmöller Jürgen, Butkiewicz Dorota, Cascorbi Ingolf, Clapper Margie L, Garte Seymour, Haugen Aage, Hirvonen Ari, Anttila Sisko, Kalina Ivan, Le Marchand Loïc, London Stephanie J, Rannug Agneta, Romkes Marjorie, Salagovic Jan, Schoket Bernadette, Gaspari Laura, Taioli Emanuela
Abstract excerpt
Polymorphisms for genes encoding the metabolic enzymes cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) might contribute to the variability in individual susceptibility to lung cancer. The role of CYP1A1 and GSTM1 in lung carcinogenesis might be more important at low levels of exposure to carcinogens. Non-smokers represent a population at low exposure, however, they are often overlooked...
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