CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls.

doi:10.1002/ijc.10995

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Article

CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls.

International journal of cancer - 1 May 2003

Vineis Paolo, Veglia Fabrizio, Benhamou Simone, Butkiewicz Dorota, Cascorbi Ingolf, Clapper Margie L, Dolzan Vita, Haugen Aage, Hirvonen Ari, Ingelman-Sundberg Magnus, Kihara Masahiro, Kiyohara Chikako, Kremers Pierre, Le Marchand Loic, Ohshima Susumu, Pastorelli Roberta, Rannug Agneta, Romkes Marjorie, Schoket Bernadette, Shields Peter, Strange Richard C, Stucker Isabelle, Sugimura Haruhiko, Garte Seymour, Gaspari Laura, Taioli Emanuela

Abstract excerpt

CYP1A1 is involved in the metabolism of benzopyrene, a suspected lung carcinogen; it is therefore conceivable that genetically determined variations in its activity modify individual susceptibility to lung cancer. The role of the CYP1A1 MspI polymorphism in lung cancer has been widely studied but has not been fully clarified. We have included 2,451 cases and 3,358 controls in a pooled analysis of 22 case-control...

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PMID: 12594823
DOI: 10.1002/ijc.10995

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