Article
Analysis of CYP1A1 exon 7 polymorphisms by PCR-SSCP in a Brazilian population and description of two novel gene variations.
Mutation research - 22 Mar 2004
Amorim Lidia Maria Fonte, Lotsch Priscila Falagan, Simão Td Tatiana de Almeida, Gallo Cláudia Vitória de Moura, Pinto Luis Felipe Ribeiro
Abstract excerpt
CYP1A1 polymorphisms have been associated with a higher risk to develop lung cancer, particularly in Japanese. The type and the frequency of the polymorphisms can vary according to the ethnicity. In the present study, we aimed to determine the frequency of CYP1A1(*)2B and (*)4, and to look for other possible polymorphisms that may happen in exon 7 in individuals from Rio de Janeiro, an ethnic mixed population...
Topics
- Base Pairing
- Black People
- Brazil
- Cytochrome P-450 CYP1A1
- Exons
- Gene Frequency
- Genetic Variation
- Genetics, Population
- Humans
- Polymerase Chain Reaction
- Polymorphism, Genetic