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Article

Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer.

The International journal of biological markers - 1 Jan 2000

Pereira Serafim P V, Cotrim Guerreiro da Silva I D, Manoukias Forones N

Abstract excerpt

AIMS AND BACKGROUND: The enzyme cytochrome P450 plays an important role in the metabolization and detoxification of various compounds. CYP1A1 is a polymorphic enzyme and some of its alleles have been correlated with an increased risk of developing various types of cancer. The aim of this study was to investigate the incidence of the polymorphism A-->G (Ile462Val, exon 7) in colorectal cancer patients and the...

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PMID: 18409146
DOI: 10.1177/172460080802300103

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