Article
CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women.
Cancer letters - 28 Oct 2004
Yang Xiaohong R, Wacholder Sholom, Xu Zhaoyi, Dean Michael, Clark Vanessa, Gold Bert, Brown Linda M, Stone B J, Fraumeni Joseph F, Caporaso Neil E
Abstract excerpt
We examined CYP1A1 (I462V) and GSTM1 null polymorphisms in 200 female cases and 144 female controls selected from a population-based case-control study of lung cancer conducted in northeast China, where the rates of lung cancer among Chinese women are especially high. The CYP1A1 codon 462 point mutation in exon 7 (I462V) causes an Ile-Val substitution near the heme binding site. This mutation correlates with...
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