Article
Genetics of CYP1A1: coamplification of specific alleles by polymerase chain reaction and association with breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 1994
Rebbeck T R, Rosvold E A, Duggan D J, Zhang J, Buetow K H
Abstract excerpt
CYP1A1 is a gene of the cytochrome P-450 family that has been proposed to be a biomarker of cancer risk. We introduce a polymerase chain reaction-based assay to measure allelic variability in exon 7 of the CYP1A1 gene. This genetic variant is associated with an amino acid change at residue 462 in...
Topics
- Adult
- Alleles
- Aryl Hydrocarbon Hydroxylases
- Biomarkers, Tumor
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 15
- Cytochrome P-450 Enzyme System
- Exons
- Gene Amplification
- Gene Frequency
- Genetic Linkage
- Genetic Variation
- Humans