Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G), and a T to C mutation in the 3'-flanking region.

doi:10.1007/BF00189321

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Article

Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G), and a T to C mutation in the 3'-flanking region.

The Clinical investigator - 1 Feb 1994

Drakoulis N, Cascorbi I, Brockmöller J, Gross C R, Roots I

Abstract excerpt

Genetic differences in the metabolism of carcinogens may codetermine individual predisposition to cancer. Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1. Two point mutations have been reported, m1...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Base Sequence
Biotransformation
Carcinogens
Carcinoma, Bronchogenic
Cytochrome P-450 Enzyme System
Exons
Female
Gene Frequency
Genes
Genetic Predisposition to Disease
Humans
Lung Diseases
Lung Neoplasms
Male

Source

Open in PubMed

Identifiers

PMID: 7912124
DOI: 10.1007/BF00189321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7912124-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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