Article
CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2000
London S J, Yuan J M, Coetzee G A, Gao Y T, Ross R K, Yu M C
Abstract excerpt
Cytochrome P450 (CYP) CYP1A1 activates tobacco-related carcinogens. A point mutation at codon 462 in exon 7 of CYP1A1 results in a substitution of isoleucine by valine near the heme binding site. This mutation is rare in Caucasians but common in Japanese populations, in which association with increased risk of lung cancer has been reported. There are few data in other Asian populations. We investigated this I462V...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.