Mutation in SF3B1 gene promotes formation of polyploid giant cells in Leukemia cells.

Abstract excerpt

Giant cells with polyploidy, termed polyploid giant cells, have been observed during normal growth, development, and pathologic states, such as solid cancer progression and resistance to therapy. Functional studies of polyploidal giant cancer cells (PGCC) provided evidence that they arise when normal diploid cells are stressed, show stem cell-like properties, and give rise to tumors. In the present study, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Giant Cells
• Share to Leukemia
• Share to Microtubule and mitosis dynamics