Article
A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicity.
Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 1995
Lotem J, Sachs L
Abstract excerpt
Myeloid leukemic M1 cells that do not express p53 and transfected M1 clones that constitutively express the [Val135]p53 mutant or deregulated c-myc or coexpressing both genes grew autonomously in culture with a similar growth rate and cloning efficiency. Expression of deregulated c-myc in M1 leuk...
Topics
- Animals
- Apoptosis
- Blotting, Northern
- Cell Division
- Clone Cells
- DNA Damage
- Gene Expression Regulation, Leukemic
- Leukemia, Experimental
- Leukemia, Myeloid
- Mice
- Mutation
- Proto-Oncogene Proteins c-myc
- Survival Analysis
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53