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Article

Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole

1 Sept 1999

Abstract excerpt

The proportions of aneuploid/polyploid versus euploid cells formed after treatment with spindle poisons like nocodazole are of course dependent on the relative survival of cells with numerical chromosome aberrations. This work aimed at studying the survival of polyploid cells formed after treatment with a nocodazole concentration sufficient to significantly decrease tubulin polymerization (0.1 microg/ml). First,...

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PMID: 10473656
DOI: 10.1093/mutage/14.5.513

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