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Article

Multinucleated Giant Cancer Cells Produced in Response to Ionizing Radiation Retain Viability and Replicate Their Genome.

International journal of molecular sciences - 8 Feb 2017

Mirzayans Razmik, Andrais Bonnie, Scott April, Wang Ying W, Kumar Piyush, Murray David

Abstract excerpt

Loss of wild-type p53 function is widely accepted to be permissive for the development of multinucleated giant cells. However, whether therapy-induced multinucleation is associated with cancer cell death or survival remains controversial. Herein, we demonstrate that exposure of p53-deficient or p21WAF1 (p21)-deficient solid tumor-derived cell lines to ionizing radiation (between 2 and 8 Gy) results in the...

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Identifiers

PMID: 28208747
DOI: 10.3390/ijms18020360
PMCID: PMC5343895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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