Article
p53 accumulation in polynuclear-giant-cells.
Virchows Archiv : an international journal of pathology - 1 Jan 1994
Wiethege T, Voss B, Müller K M
Abstract excerpt
Accumulation of p53 has been reported in nearly all malignant human tumours. Macrophage derived giant cells of sarcoid granulomas in human lung tissue also show intense staining for p53 while normal alveolar macrophages remain unstained. Since sarcoid giant cells are not considered to be either pre-neoplastic nor to exhibit p53 gene mutations, two different physiological functions of p53 may be illustrated....
Topics
- Animals
- Cell Cycle
- Cells, Cultured
- Female
- Giant Cells
- Granuloma
- Immunohistochemistry
- Macrophages, Alveolar
- Mutation
- Nuclear Proteins
- Polymerase Chain Reaction
- Proliferating Cell Nuclear Antigen