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Article

The CREB family of activators is required for endochondral bone development.

Development (Cambridge, England) - 1 Feb 2001

Long F, Schipani E, Asahara H, Kronenberg H, Montminy M

Abstract excerpt

We have evaluated the importance of the CREB family of transcriptional activators for endochondral bone formation by expressing a potent dominant negative CREB inhibitor (A-CREB) in growth plate chondrocytes of transgenic mice. A-CREB transgenic mice exhibited short-limbed dwarfism and died minutes after birth, apparently due to respiratory failure from a diminished rib cage circumference. Consistent with the...

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Identifiers

PMID: 11171337
DOI: 10.1242/dev.128.4.541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The CREB family of activators is required for endochondral bone development.PMID 11171337Read ↗

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Expression of bone-specific genes by hypertrophic chondrocytes: Implications of the complex functions of the hypertrophic chondrocyte during endochondral bone developmentSemantic proximity Read ↗

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