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Article

Targeted disruption of expression site-associated gene-1 in bloodstream-form Trypanosoma brucei.

Molecular and biochemical parasitology - 18 Oct 1996

Carruthers V B, Navarro M, Cross G A

Abstract excerpt

Each variant surface glycoprotein (Vsg) expression site (ES) in bloodstream-form Trypanosoma brucei is a polycistronic transcription unit containing several distinct expression site-associated genes (esag), in addition to a single vsg gene. esag1 genes from different ESs encode a highly polymorphic family of membrane-associated glycoproteins, whose function is unknown. In the hope of producing a phenotype that...

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PMID: 8892306
DOI: 10.1016/0166-6851(96)02672-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Targeted disruption of expression site-associated gene-1 in bloodstream-form Trypanosoma brucei.PMID 8892306Read ↗

Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei.Semantic proximity Read ↗

Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4‐like subfamilySemantic proximity Read ↗

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomesSemantic proximity Read ↗

Delineation of the regulated Variant Surface Glycoprotein gene expression site domain of Trypanosoma brucei.Semantic proximity Read ↗

Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream.Semantic proximity Read ↗

A new VSG expression site-associated gene (ESAG) in the promoter region of Trypanosoma brucei encodes a protein with 10 potential transmembrane domains.Semantic proximity Read ↗

Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma bruceiSemantic proximity Read ↗

Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: expression site control from both ends?Semantic proximity Read ↗

Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activatorSemantic proximity Read ↗

A novel ISWI is involved in VSG expression site downregulation in African trypanosomes.Semantic proximity Read ↗

Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei.Semantic proximity Read ↗

Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites.Semantic proximity Read ↗

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