ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.

doi:10.1073/pnas.90.19.8977

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Article

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1993

Moser A R, Mattes E M, Dove W F, Lindstrom M J, Haag J D, Gould M N

Abstract excerpt

ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are mor...

Topics

9,10-Dimethyl-1,2-benzanthracene
Adenocarcinoma
Animals
Crosses, Genetic
Ethylnitrosourea
Female
Genes, APC
Genetic Predisposition to Disease
Hyperplasia
Male
Mammary Glands, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mammary Neoplasms, Animal

Mammary Neoplasms, Experimental

Metaplasia

Mice

Mice, Inbred C57BL

Mice, Mutant Strains

Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 8415640
DOI: 10.1073/pnas.90.19.8977
PMCID: PMC47484

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8415640-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.PMID 8415640Read ↗

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Semantic proximity Read ↗

ApcMin: A mouse model for intestinal and mammary tumorigenesisSemantic proximity Read ↗

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.Semantic proximity Read ↗

Action of Min and Mom1 on neoplasia in ectopic intestinal grafts.Semantic proximity Read ↗

Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice.Semantic proximity Read ↗

Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min‐FCCC) mice with significantly increased numbers of colorectal adenomasSemantic proximity Read ↗

Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice.Semantic proximity Read ↗

Bacterial infection promotes colon tumorigenesis in Apc(Min/+) mice.Semantic proximity Read ↗

Mammary tumorigenesis in ApcMin/+ mice is enhanced by X irradiation with a characteristic age dependence.Semantic proximity Read ↗

Identification of novel modifier loci of Apc Min affecting mammary tumor development.Semantic proximity Read ↗

Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse.Semantic proximity Read ↗

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.Semantic proximity Read ↗

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