Article
Relationship between mutations in parC and gyrA of clinical isolates of Streptococcus pneumoniae and resistance to ciprofloxacin and grepafloxacin.
Journal of medical microbiology - 1 Dec 1999
Stewart B A, Johnson A P, Woodford N
Abstract excerpt
The mechanisms of resistance to ciprofloxacin and grepafloxacin were studied in 54 clinical isolates of Streptococcus pneumoniae. Restriction fragment length polymorphism analysis following HinfI digestion was used with DNA sequencing to identify mutations in the quinolone resistance-determining...
Topics
- Anti-Infective Agents
- Ciprofloxacin
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Deoxyribonucleases, Type II Site-Specific
- Drug Resistance, Microbial
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests
- Mutation
- Piperazines
- Pneumococcal Infections
- Polymorphism, Restriction Fragment Length
- Sequence Analysis, DNA
- Streptococcus pneumoniae