Article
A novel parC mutation potentiating fluoroquinolone resistance in Klebsiella pneumoniae and Escherichia coli clinical isolates.
Journal of infection in developing countries - 28 Feb 2022
Yakout Marwa Atef, Ali Ghada Hani
Abstract excerpt
INTRODUCTION: Resistance to fluoroquinolones is mainly due to point mutations that gave rise to amino acid substitutions in the quinolone resistance-determining regions of either gyrA or parC genes, which may be augmented by plasmid mediated resistance. Accordingly, the main aim of the study was...
Topics
- Anti-Bacterial Agents
- DNA Gyrase
- DNA Topoisomerase IV
- Escherichia coli
- Fluoroquinolones
- Klebsiella pneumoniae
- Mutation