Article
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy - 1 Mar 1997
Deguchi T, Fukuoka A, Yasuda M, Nakano M, Ozeki S, Kanematsu E, Nishino Y, Ishihara S, Ban Y, Kawada Y
Abstract excerpt
We determined a partial sequence of the Klebsiella pneumoniae parC gene, including the region analogous to the quinolone resistance-determining region of the Escherichia coli gyrA gene, and examined 26 clinical strains of K. pneumoniae for an association of alterations in GyrA and ParC with susce...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- Cephalosporins
- Ciprofloxacin
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Genes, Bacterial
- Humans
- Klebsiella Infections
- Klebsiella pneumoniae
- Molecular Sequence Data