Article
Peculiar allelotype associated with susceptibility to neuroblastoma.
Genes, chromosomes & cancer - 1 Sept 1996
Perri P, Pession A, Mazzocco K, Strigini P, Iolascon A, Basso G, Tonini G P
Abstract excerpt
Human neuroblastoma (NB) is characterized genetically by deletions of the short arm of chromosome I and by MYCN amplification. Loss of heterozygosity (LOH) has been found frequently for region 1p36. We have studied restriction fragment length polymorphisms (RFLPs) by using anonymous and hypervariable region (HVR) sequences to demonstrate LOH for 1p loci in 50 Italian neuroblastoma patients. Twelve cases (25%)...
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